Fig. 1 · Structure
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SPD-502 sodium
iGluR
SPD-502 sodium is a selective antagonist of the AMPA receptor, primarily targeting the iGluR for neuroprotective effects. This compound exhibits a high affinity (IC50 = 0.043 μM) and competitively inhibits AMPA-induced activity in rat cortical membranes and cultured mouse cortical neurons. In vivo studies demonstrate that SPD-502 sodium blocks AMPA-evoked spike activity in the hippocampus, effectively increasing seizure threshold in mice and offering significant protection against ischemia-induced neuronal damage in gerbils. These properties suggest that SPD-502 sodium is valuable for researching neurodegenerative diseases linked to glutamate excitotoxicity.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 205645-02-9 |
| Applications | iGluR |
| Formula | C24H27N4NaO7S |
| Molecular Weight | 538.55 |
| Synonyms | NS-1209 sodium |
| SMILES | O=C(C(CCO)O/N=C1C(NC2=C(CN(CC3)C)C3=C(C4=CC=C(S(=O)(N(C)C)=O)C=C4)C=C2\1)=O)O[Na] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.