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Form	MW
SPD-502 This page	516.57
SPD-502 sodium	538.55

SPD-502

iGluR

SPD-502 is a selective antagonist of the AMPA receptor, primarily targeting iGluR to inhibit glutamate-mediated excitatory signaling. It demonstrates a high binding affinity (IC50 = 0.043 μM) and effectively antagonizes AMPA-induced responses in rat cortical membranes and cultured mouse cortical neurons. In vivo studies reveal that SPD-502 significantly elevates the seizure threshold in mice and protects hippocampal neurons from ischemic damage in gerbils. These properties make SPD-502 a valuable reagent for exploring neuroprotective strategies in neurodegenerative diseases linked to glutamate excitotoxicity.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	245063-59-6
Applications	iGluR
Formula	C₂₄H₂₈N₄O₇S
Molecular Weight	516.57
Synonyms	NS-1209
SMILES	O=C(N1)/C(C2=C1C3=C(C(C4=CC=C(S(N(C)C)(=O)=O)C=C4)=C2)CCN(C)C3)=N\OC(C(O)=O)CCO

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.