SPDB-sulfo

Catalog No.: A43239
ADC Linker
SPDB-sulfo is a glutathione-cleavable linker specifically designed for antibody-drug conjugates (ADCs). It facilitates the selective release of cytotoxic agents in tumor cells, enhancing the therapeutic efficacy of the ADCs while minimizing systemic toxicity. This linker is essential in the development of targeted cancer therapies, allowing for precise delivery of drugs to malignant tissues.
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5mg
10mg
50mg
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Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionSPDB-sulfo is a glutathione-cleavable linker specifically designed for antibody-drug conjugates (ADCs). It facilitates the selective release of cytotoxic agents in tumor cells, enhancing the therapeutic efficacy of the ADCs while minimizing systemic toxicity. This linker is essential in the development of targeted cancer therapies, allowing for precise delivery of drugs to malignant tissues.
Product Information
Catalog NumA43239
FormulaC13H14N2O7S3
Molecular Weight406.45
CAS Number1628113-16-5
SMILESO=C(ON1C(C(S(=O)(O)=O)CC1=O)=O)CCCSSC2=NC=CC=C2
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