Fig. 1 · Structure
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SPOP-IN-2
SPOP Inhibitor
SPOP-IN-2 is a selective inhibitor of the Speckle-type POZ protein (SPOP) with an IC50 value of 0.58 μM. This compound effectively disrupts the interaction between SPOP and its substrates, leading to inhibited proliferation in clear cell renal cell carcinoma (ccRCC) models. SPOP-IN-2 serves as a valuable tool for investigating the role of SPOP in cancer biology and may aid in the development of targeted therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3031640-86-2 |
| Applications | SPOP Inhibitor |
| Formula | C15H13ClN2O5S |
| Molecular Weight | 368.79 |
| SMILES | O=C1[C@@H](NC(C2=CC=C(CCl)O2)=O)[C@@]3([H])SCC(C=C)=C(C(O)=O)N31 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.