Fig. 1 · Structure
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SR33805
Ca2+ Antagonist
SR33805 is a potent calcium channel antagonist that selectively inhibits L-type calcium channels, with EC50 values of 4.1 nM under depolarized conditions and 33 nM in polarized conditions. This compound is primarily used in research related to cardiac physiology and may provide insights into mechanisms underlying acute and chronic heart failure. Its ability to selectively modulate calcium influx makes it a valuable tool for studying calcium signaling in various cardiovascular contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 121345-64-0 |
| Applications | Ca2+ Antagonist |
| Formula | C32H40N2O5S |
| Molecular Weight | 564.74 |
| SMILES | O=S(C1=CC=C(OCCCN(C)CCC2=CC=C(OC)C(OC)=C2)C=C1)(C3=C(C(C)C)N(C)C4=C3C=CC=C4)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.