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ST13

HDAC1/HDAC2 Inhibitor

ST13 is a selective inhibitor of HDAC1 and HDAC2, exhibiting IC50 values of 23 nM and 49 nM, respectively. It offers weak inhibition of HDAC3 and HDAC6, with IC50 values of 4.30 μM and >10 μM, respectively. The binding mechanism of ST13 involves an initial rapid formation of a collision complex followed by a slow conversion to a stable complex. This compound has demonstrated the ability to induce apoptosis in cancer cells and is useful for research on melanoma and triple-negative breast cancer.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1013620-98-8
Applications	HDAC1/HDAC2 Inhibitor
Formula	C₂₁H₁₈N₂O₃
Molecular Weight	346.38
SMILES	CC(NC1=CC=C(C(NC2=C(O)C=CC(C3=CC=CC=C3)=C2)=O)C=C1)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.