Casein Kinase Inhibitors: Silmitasertib

Cat. No.: A24013

CAS No.: 2367619-87-0

FPFT-2216

FPFT-2216 is a “molecular glue” degrader that facilitates the proteasomal degradation of multiple target proteins, including phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1) and Aiolos (IKZF3), as well as casein kinase 1α (CK1α). By promoting selective ubiquitination through E3 ligase recruitment, FPFT-2216 modulates key regulatory pathways and holds promise for research in oncology and inflammatory diseases.

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Cat. No.: A24018

CAS No.: 3026986-17-1

SJ3149

SJ3149 is a selective and potent molecular glue degrader that targets casein kinase 1α (CK1α) for proteasomal degradation. By promoting CK1α elimination, SJ3149 exhibits broad antiproliferative activity across various cancer models. It serves as a valuable tool for exploring CK1α-dependent signaling pathways and holds promise for therapeutic development in oncology research.

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Cat. No.: A24019

CAS No.: 2766385-56-0

TMX-4116

TMX-4116 is a selective degrader of casein kinase 1α (CK1α), demonstrating preferential degradation activity with DC₅₀ values below 200 nM in MOLT4, Jurkat, and MM.1S cell lines. By targeting CK1α for proteasomal degradation, TMX-4116 offers a promising tool for investigating CK1α function and holds potential for therapeutic research in multiple myeloma and related hematologic malignancies.

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Cat. No.: A30176

CAS No.: 2564486-44-6

BMS-986397

BMS-986397 is a selective and orally active cereblon-based molecular glue degrader targeting casein kinase 1α (CK1α). This compound effectively induces apoptosis and cell cycle arrest in acute myeloid leukemia (AML) cells, positioning it as a valuable tool for research in the fields of AML and high-risk myelodysplastic syndromes (HR-MDS). Its unique mechanism offers potential for elucidating CK1α's role in these malignancies.

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5 mg

$160.00

10 mg

$255.00

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Cat. No.: A36880

CAS No.: 2766385-92-4

TMX-4113

TMX-4113 is a degrader targeting phosphodiesterase 6D (PDE6D) and casein kinase 1α (CK1α). This compound exhibits significant biological activity in the degradation of these proteins, making it a valuable tool for investigating their roles in cancer research. TMX-4113 can facilitate studies aimed at elucidating the molecular mechanisms underlying tumor progression and treatment responses.

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5 mg

$330.00

10 mg

$570.00

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Cat. No.: A36894

CAS No.: 2881012-96-8

CK1α degrader-1

CK1α degrader-1 is a selective degrader of casein kinase 1 alpha (CK1α) that exhibits a DC50 of 0.105 μM. This compound effectively promotes the degradation of CK1α, thereby influencing cellular signaling pathways related to cancer progression. It serves as a valuable tool for investigating the role of CK1α in cancer biology and therapeutic interventions.

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Cat. No.: A57251

CAS No.: 3090685-34-7

WEE1 degrader 1

WEE1 Degrader 1 is a CRBN-dependent molecular glue degrader that targets WEE1 and casein kinase 1α (CK1α) with sub-2 nM DC50 values for both proteins. This compound effectively induces the proteasomal degradation of its targets, providing a valuable tool for studying cell cycle regulation. WEE1 Degrader 1 is particularly relevant in the research of acute lymphoblastic leukemia, acute monocytic leukemia, acute promyelocytic leukemia, colorectal adenocarcinoma, and diffuse large B-cell lymphoma.

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5 mg

$445.00

10 mg

$730.00

All 5 sizes