SU0383 is a dual inhibitor of MTH1 and OGG1, demonstrating IC50 values of 0.034 μM and 0.49 μM, respectively. This compound induces cytotoxicity in cancer cells and enhances their sensitivity to oxidative stress, while exhibiting minimal toxicity in normal cells. SU0383 is suitable for applications in cancer research, particularly in studies focused on oxidative stress responses and therapeutic strategies targeting DNA repair mechanisms.
SU0383 is a dual inhibitor of MTH1 and OGG1, demonstrating IC50 values of 0.034 μM and 0.49 μM, respectively. This compound induces cytotoxicity in cancer cells and enhances their sensitivity to oxidative stress, while exhibiting minimal toxicity in normal cells. SU0383 is suitable for applications in cancer research, particularly in studies focused on oxidative stress responses and therapeutic strategies targeting DNA repair mechanisms.
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