Fig. 1 · Structure
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Suc-YVAD-pNA
ICE Substrate
Suc-YVAD-pNA is a substrate specifically designed for the interleukin-1β-converting enzyme (ICE), a cysteine protease that facilitates the conversion of pre-interleukin-1β (pre-IL-1β) to its active form. This reagent is instrumental in studying apoptosis and inflammatory processes through the modulation of interleukin-1β signaling. Its application extends to various research fields, including immunology and cell biology, where understanding ICE activity is crucial for elucidating cytokine regulation and its implications in disease states.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 208264-84-0 |
| Applications | ICE Substrate |
| Formula | C31H38N6O12 |
| Molecular Weight | 686.67 |
| SMILES | CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)Nc1ccc(cc1)N(=O)=O |@@:1| |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.