Succinyl phosphonate is a selective inhibitor of α-ketoglutarate dehydrogenase (KGDHC) and 2-oxoglutarate dehydrogenase (OGDH). It effectively inhibits KGDHC activity in various cell types including muscle, bacterial, brain, and cultured human fibroblasts, demonstrating distinct effects on cell viability influenced by metabolic conditions in cancer cells. Additionally, succinyl phosphonate trisodium salt is known to reduce glutamate-induced reactive oxygen species (ROS) production in glutamate-stimulated hippocampal neurons, making it a valuable tool for studies in metabolic pathways and neurotoxicity.
Succinyl phosphonate is a selective inhibitor of α-ketoglutarate dehydrogenase (KGDHC) and 2-oxoglutarate dehydrogenase (OGDH). It effectively inhibits KGDHC activity in various cell types including muscle, bacterial, brain, and cultured human fibroblasts, demonstrating distinct effects on cell viability influenced by metabolic conditions in cancer cells. Additionally, succinyl phosphonate trisodium salt is known to reduce glutamate-induced reactive oxygen species (ROS) production in glutamate-stimulated hippocampal neurons, making it a valuable tool for studies in metabolic pathways and neurotoxicity.
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