Sunitinib-d10 is a deuterium-labeled variant of Sunitinib, a multi-targeted receptor tyrosine kinase inhibitor that primarily targets VEGFR2 and PDGFRβ with IC50 values of 80 nM and 2 nM, respectively. As an ATP-competitive inhibitor, Sunitinib-d10 effectively blocks autophosphorylation of Ire1α, thereby inhibiting its RNase activity. This stable isotope is utilized in pharmacokinetic studies and metabolic labeling, facilitating deeper insights into kinase signaling pathways and drug metabolism.
Sunitinib-d10 is a deuterium-labeled variant of Sunitinib, a multi-targeted receptor tyrosine kinase inhibitor that primarily targets VEGFR2 and PDGFRβ with IC50 values of 80 nM and 2 nM, respectively. As an ATP-competitive inhibitor, Sunitinib-d10 effectively blocks autophosphorylation of Ire1α, thereby inhibiting its RNase activity. This stable isotope is utilized in pharmacokinetic studies and metabolic labeling, facilitating deeper insights into kinase signaling pathways and drug metabolism.
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