Fig. 1 · Structure
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Suramin sodium salt
PTPases Inhibitor
Suramin sodium salt acts as a reversible and competitive inhibitor of protein-tyrosine phosphatases (PTPases). It demonstrates potent inhibitory activity against sirtuins, specifically SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM). Additionally, Suramin sodium salt inhibits reverse transcriptase and shows strong efficacy as a SARS-CoV-2 RNA-dependent RNA polymerase inhibitor. Its diverse biochemical properties make it a valuable tool for research in antiparasitic, anti-neoplastic, and anti-angiogenic studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 129-46-4 |
| Applications | PTPases Inhibitor |
| Formula | C51H34N6Na6O23S6 |
| Molecular Weight | 1429.17 |
| Synonyms | Suramin hexasodium salt |
| SMILES | O=C(NC1=CC(C(NC2=CC(C(NC3=CC=C(S(=O)(O[Na])=O)C4=CC(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C34)=O)=CC=C2C)=O)=CC=C1)NC5=CC(C(NC6=CC(C(NC7=CC=C(S(=O)(O[Na])=O)C8=CC(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C78)=O)=CC=C6C)=O)=CC=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.