Fig. 1 · Structure
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Surfen dihydrochloride
HS Antagonist
Surfen dihydrochloride is a potent heparan sulfate antagonist that effectively inhibits FGF2 binding and subsequent signal transduction. This compound demonstrates significant biological activity by reducing tau hyperphosphorylation and inhibiting the activity of recombinant uronyl 2-O-sulfotransferase, exhibiting an IC50 of approximately 2 μM. Additionally, Surfen dihydrochloride has been shown to inhibit HSV-1 viral infection and affect neural differentiation, delay remyelination, and alleviate experimental autoimmune encephalomyelitis (EAE), making it a valuable reagent for research in neurobiology and viral pathogenesis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 5424-37-3 |
| Applications | HS Antagonist |
| Formula | C21H22Cl2N6O |
| Molecular Weight | 445.34 |
| Synonyms | Aminoquinuride dihydrochloride |
| SMILES | O=C(NC1=CC=C2N=C(C)C=C(N)C2=C1)NC3=CC=C4N=C(C)C=C(N)C4=C3.Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.