Fig. 1 · Structure
Documents & Downloads
Surfen
HS Antagonist
Surfen is a potent heparan sulfate antagonist that inhibits FGF2 binding and its associated signal transduction pathways. By binding to glycosaminoglycans, Surfen effectively reduces tau hyperphosphorylation and inhibits the activity of recombinant uronyl 2-O-sulfotransferase, with an IC50 of approximately 2 μM. Additionally, Surfen demonstrates antiviral activity against HSV-1 infection and impedes neural differentiation while delaying remyelination. This compound is valuable for research applications related to neurodegenerative diseases and viral pathogenesis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 3811-56-1 |
| Applications | HS Antagonist |
| Formula | C21H20N6O |
| Molecular Weight | 372.42 |
| Synonyms | Aminoquinuride |
| SMILES | O=C(NC1=CC2=C(N=C(C)C=C2N)C=C1)NC3=CC4=C(N=C(C)C=C4N)C=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.