TAC 363 is a selective antagonist of the tachykinin NK-2 receptor, demonstrating considerable potency with a pA2 value of 9.82, reflecting a rightward shift in the contractile response curve induced by Neurokinin A. While TAC 363 exhibits a weak antagonistic effect on NK-1 receptors, it effectively inhibits Neurokinin A-induced bronchoconstriction in guinea pigs, with an ED50 of 0.3 mg/kg. This compound is valuable for research into bronchial asthma and related respiratory conditions.
TAC 363 is a selective antagonist of the tachykinin NK-2 receptor, demonstrating considerable potency with a pA2 value of 9.82, reflecting a rightward shift in the contractile response curve induced by Neurokinin A. While TAC 363 exhibits a weak antagonistic effect on NK-1 receptors, it effectively inhibits Neurokinin A-induced bronchoconstriction in guinea pigs, with an ED50 of 0.3 mg/kg. This compound is valuable for research into bronchial asthma and related respiratory conditions.
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