Fig. 1 · Structure
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TAC 363
Tachykinin NK-2 Receptor Antagonist
TAC 363 is a selective antagonist of the tachykinin NK-2 receptor, demonstrating considerable potency with a pA2 value of 9.82, reflecting a rightward shift in the contractile response curve induced by Neurokinin A. While TAC 363 exhibits a weak antagonistic effect on NK-1 receptors, it effectively inhibits Neurokinin A-induced bronchoconstriction in guinea pigs, with an ED50 of 0.3 mg/kg. This compound is valuable for research into bronchial asthma and related respiratory conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 172081-08-2 |
| Applications | Tachykinin NK-2 Receptor Antagonist |
| Formula | C38H48N8O6 |
| Molecular Weight | 712.84 |
| SMILES | O=C(NCCOCC1=CC=CC=C1)N(CC2=CC=CC=C2)NC([C@@H](NC([C@H](CCC(N)=O)NC(NC(C)(C)C)=O)=O)CC3=CNC4=CC=CC=C34)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.