Fig. 1 · Structure
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Tafluprost acid
FP Receptor Agonist
Tafluprost acid is a selective agonist of the prostanoid FP receptor, demonstrating high affinity with Ki and EC50 values of 0.4 nM and 0.53 nM, respectively. Its binding affinity for the prostanoid EP3 receptor is significantly lower, with an IC50 of 67 nM, indicating a preferential interaction with the FP receptor. Tafluprost acid is primarily utilized in glaucoma research, making it a valuable tool for studies focused on intraocular pressure regulation and ocular pharmacology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 209860-88-8 |
| Applications | FP Receptor Agonist |
| Formula | C22H28F2O5 |
| Molecular Weight | 410.45 |
| Synonyms | AFP-172 |
| SMILES | O[C@H]([C@@H]1C/C=C\CCCC(O)=O)C[C@H]([C@@H]1/C=C/C(F)(COC2=CC=CC=C2)F)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.