Cellular Effect
| Cell Line | Activity | Value | Description | Reference |
|---|---|---|---|---|
| PBMC | IC50 | 9.5 nM | Decrease in Tc17 cell differentiation in CD8+ T cells from human PBMC cells cultured under the Tc17-skewing conditions measured after 6 days | [PMID: 30010338] |
Fig. 1 · Structure
Documents & Downloads
TAK-828F
Cat. No.
A19611
CAS
1854901-94-2
RORγt inverse agonist
TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (binding IC50=1.9 nM, reporter gene IC50=6.1 nM).
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inverse Agonist |
| CAS Number | 1854901-94-2 |
| Applications | RORγt inverse agonist |
| Formula | C28H32FN3O5 |
| Molecular Weight | 509.57 |
| SMILES | CC1(C)C2=C(F)C=C(NC([C@@H]3N(C([C@@H]4C[C@H](CC(O)=O)C4)=O)CCC5=C3C=CC(OC)=N5)=O)C=C2CC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.