Fig. 1 · Structure
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Tanomastat
MMPs Inhibitor
Tanomastat is a non-peptidic biphenyl inhibitor of matrix metalloproteinases (MMPs), featuring a Zn-binding carboxyl group that enhances its efficacy. It demonstrates potent inhibition with Ki values of 11 nM for MMP-2, 143 nM for MMP-3, 301 nM for MMP-9, and 1470 nM for MMP-13. Tanomastat exhibits significant anti-invasive and antimetastatic properties in various experimental tumor models, making it a valuable tool for cancer research and therapeutic investigations targeting MMP activity.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 179545-77-8 |
| Applications | MMPs Inhibitor |
| Formula | C23H19ClO3S |
| Molecular Weight | 410.91 |
| Synonyms | BAY 12-9566 |
| SMILES | ClC1=CC=C(C2=CC=C(C(C[C@H](CSC3=CC=CC=C3)C(O)=O)=O)C=C2)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.