Cellular Effect
| Cell Line | Activity | Value | Description | Reference |
|---|---|---|---|---|
| HUVEC | GI50 | > 10 μM | Cytotoxicity against HUVEC assessed as inhibition of VEGF-independent growth after 72 hrs by CellTiter-Glo method | [PMID: 26717201] |
Fig. 1 · Structure
Documents & Downloads
Pamufetinib (TAS-115)
Cat. No.
A21533
CAS
1190836-34-0
VEGFR/c-Met/HGFR inhibitor
In Stock
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1190836-34-0 |
| Applications | VEGFR/c-Met/HGFR inhibitor |
| Formula | C27H23FN4O4S |
| Molecular Weight | 518.56 |
| Synonyms | TAS-115 |
| SMILES | O=C(C1=C(OC)C=C2N=CC=C(OC3=CC=C(NC(NC(CC4=CC=CC=C4)=O)=S)C=C3F)C2=C1)NC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.