Fig. 1 · Structure
Documents & Downloads
TASIN-30
EBP Inhibitor
TASIN-30 is a selective inhibitor of the enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydratase, targeting cholesterol biosynthesis by blocking the production of 7-dehydrocholesterol (7-DHC). With an EC50 of 0.097 μM, TASIN-30 effectively depletes downstream sterols, disrupts lipid raft integrity in tumor cells, and inhibits cell proliferation. This compound induces ferroptosis and apoptosis through reduced 7-DHC levels and enhanced phospholipid peroxidation. It demonstrates significant tumor suppression activity in nude mice models of osteosarcoma, making TASIN-30 a valuable tool for cancer research, particularly in osteosarcoma and colorectal cancer studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1678515-93-9 |
| Applications | EBP Inhibitor |
| Formula | C18H30N2O3S |
| Molecular Weight | 354.51 |
| SMILES | O=S(C1=C(C)C=C(C)C=C1C)(N2CCC(CC2)NCCC(C)O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.