Tau-0N4R-IN-1 is an effective inhibitor of tau 0N4R oligomerization, capable of penetrating the blood-brain barrier. This compound demonstrates significant biological activity by inhibiting tau fibrosis across different isoforms, exhibiting anti-seeding effects on tau in vitro, and dose-dependently reducing α-synuclein oligomerization and inclusions. Additionally, Tau-0N4R-IN-1 is stable in mouse microsomes and has been shown to decrease amyloid-beta plaques in brain tissues from Alzheimer's disease patients, making it a valuable reagent for neurological research and drug development.
Tau-0N4R-IN-1 is an effective inhibitor of tau 0N4R oligomerization, capable of penetrating the blood-brain barrier. This compound demonstrates significant biological activity by inhibiting tau fibrosis across different isoforms, exhibiting anti-seeding effects on tau in vitro, and dose-dependently reducing α-synuclein oligomerization and inclusions. Additionally, Tau-0N4R-IN-1 is stable in mouse microsomes and has been shown to decrease amyloid-beta plaques in brain tissues from Alzheimer's disease patients, making it a valuable reagent for neurological research and drug development.
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