Fig. 1 · Structure
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TbPTR1 inhibitor 1
Antiparasitic Agent
TbPTR1 inhibitor 1 is a potent inhibitor of kinetoplastid pteridine reductase 1 (PTR1), exhibiting an IC50 value of less than 0.1 nM for TbPTR1. This compound demonstrates significant antiparasitic activity against Trypanosoma brucei, with an effective concentration (EC50) of 0.66 μM. It is a valuable tool for research focused on developing treatments for diseases caused by kinetoplastid parasites.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2499713-65-2 |
| Applications | Antiparasitic Agent |
| Formula | C22H21N7O |
| Molecular Weight | 399.45 |
| SMILES | O=C(C1=CC=C(N(CC)CC2=CN=C(N=C(N)N=C3N)C3=N2)C=C1)C4=CC=CC=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.