Fig. 1 · Structure
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TC-SP 14
S1P1 Agonist
TC-SP 14 is a potent and orally active S1P1 agonist, exhibiting an EC50 of 0.042 μM, while demonstrating minimal activity at S1P3 with an EC50 of 3.47 μM. This compound significantly reduces blood lymphocyte counts and attenuates delayed type hypersensitivity (DTH) responses upon antigen challenge. TC-SP 14 is valuable for research focusing on immune modulation and the therapeutic potential in autoimmune diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 1257093-40-5 |
| Applications | S1P1 Agonist |
| Formula | C25H20F2N2O2S |
| Molecular Weight | 450.50 |
| SMILES | O=C(C1CN(CC2=CC=C(C3=NC4=CC(CC5=CC=CC=C5F)=CC=C4S3)C(F)=C2)C1)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.