TC-SP 14 is a potent and orally active S1P1 agonist, exhibiting an EC50 of 0.042 μM, while demonstrating minimal activity at S1P3 with an EC50 of 3.47 μM. This compound significantly reduces blood lymphocyte counts and attenuates delayed type hypersensitivity (DTH) responses upon antigen challenge. TC-SP 14 is valuable for research focusing on immune modulation and the therapeutic potential in autoimmune diseases.
TC-SP 14 is a potent and orally active S1P1 agonist, exhibiting an EC50 of 0.042 μM, while demonstrating minimal activity at S1P3 with an EC50 of 3.47 μM. This compound significantly reduces blood lymphocyte counts and attenuates delayed type hypersensitivity (DTH) responses upon antigen challenge. TC-SP 14 is valuable for research focusing on immune modulation and the therapeutic potential in autoimmune diseases.
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