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TCMDC-135051 TFA

PfCLK3 Inhibitor

TCMDC-135051 TFA is a potent and selective inhibitor of the protein kinase PfCLK3, exhibiting low off-target toxicity. This compound effectively hinders the trophozoite-to-schizont transition, disrupts transcriptional processes, and decreases the transmission of malaria to mosquito vectors. TCMDC-135051 TFA demonstrates significant antiparasitic activity, with an EC50 value of 320 nM, making it a valuable tool for malaria research and therapeutic studies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2571578-55-5
Applications	PfCLK3 Inhibitor
Formula	C₃₁H₃₄F₃N₃O₅
Molecular Weight	585.61
SMILES	O=C(O)C1=CC=C(C2=C3C(NC(C4=C(OC)C=CC(CN(CC)CC)=C4)=C3)=NC=C2)C=C1C(C)C.OC(C(F)(F)F)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.