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TDI-014925

Catalog No.: A53383
SARS-CoV-2 NSP14 Inhibitor
TDI-014925 is a potent inhibitor of the SARS-CoV-2 nonstructural protein 14 (NSP14) with an IC50 of 0.2 nM. This compound exhibits significant antiviral activity and demonstrates excellent microsomal stability without CYP inhibition. TDI-014925 is suitable for research applications related to COVID-19 and the biochemical characterization of viral methyltransferase functions.
TDI-014925 3052313-53-5 SARS-CoV-2 NSP14 Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTDI-014925 is a potent inhibitor of the SARS-CoV-2 nonstructural protein 14 (NSP14) with an IC50 of 0.2 nM. This compound exhibits significant antiviral activity and demonstrates excellent microsomal stability without CYP inhibition. TDI-014925 is suitable for research applications related to COVID-19 and the biochemical characterization of viral methyltransferase functions.
Product Information
Catalog NumA53383
FormulaC22H24FN7O3S
Molecular Weight485.53
CAS Number3052313-53-5
SMILESCC1=C(C=C(N1C)C(NCC2=C3C(C=NN3C)=CC=C2F)=O)S(=O)(N4CCC5=NNC=C5C4)=O
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Microbiology > SARS-CoV