Fig. 1 · Structure
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TDI-015051
Coronavirus Inhibitor
TDI-015051 is a selective, orally active antiviral agent that specifically inhibits the NSP14 guanine-N7 methyltransferase of coronaviruses. By binding non-competitively to substrates, TDI-015051 forms a stable ternary complex, effectively blocking the capping and methylation of viral mRNA, thus impairing viral replication and translation. It demonstrates potent antiviral activity against multiple coronaviruses, including SARS-CoV-2 and MERS, significantly reducing pulmonary viral load and inducing a moderate type I interferon-mediated immune response. TDI-015051 has IC50 values of 0.15 nM against SARS-CoV-2 and exhibits synergy with Nirmatrelvir while maintaining selectivity by not inhibiting non-coronavirus methyltransferases. This compound is suitable for research into COVID-19 and the replication mechanisms of coronaviruses.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3052313-73-9 |
| Applications | Coronavirus Inhibitor |
| Formula | C22H22FN5O4S |
| Molecular Weight | 471.50 |
| SMILES | O=S(N(CC1)CC2=C1NN=C2)(C3=C(C)N(C)C(C(NCC4=C(F)C=CC5=C4C=CO5)=O)=C3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.