Fig. 1 · Structure
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TEAD-IN-1
TEAD Autopalmitoylation Inhibitor
TEAD-IN-1 is a potent inhibitor of TEAD autopalmitoylation, exhibiting an IC50 of 603 nM. This compound enhances the interaction between TEAD and VGLL4 while simultaneously decreasing the association between YAP and TEAD. TEAD-IN-1 is applicable for researching cancer pathways and potential therapeutic interventions targeting TEAD-related signaling mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2412761-57-8 |
| Applications | TEAD Autopalmitoylation Inhibitor |
| Formula | C15H20F2N2O3S |
| Molecular Weight | 346.39 |
| SMILES | CS(=O)(NC1=CC(/C=C/C2CCC(F)(F)CC2)=C(OC)N=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.