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TEAD-IN-10

TEAD Inhibitor

TEAD-IN-10 is a covalent inhibitor primarily targeting TEAD transcription factors, demonstrating selective inhibitory activity against TEAD1 (IC50 = 14 nM), TEAD2 (IC50 = 179 nM), and TEAD3 (IC50 = 4 nM). This compound is crucial for investigating the role of TEAD proteins in cancer biology and can be utilized in various cancer research applications. Its potent activity makes it a valuable tool for studying TEAD-mediated signaling pathways and their implications in tumorigenesis.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3032196-65-6
Applications	TEAD Inhibitor
Formula	C₁₅H₁₄F₃NO
Molecular Weight	281.27
SMILES	O=C(C=C)N(C1)CC1/C=C/C2=CC=C(C(F)(F)F)C=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.