Fig. 1 · Structure
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TEAD-IN-12
TEAD Inhibitor
TEAD-IN-12 is a potent TEAD inhibitor demonstrated to have an IC50 of less than 100 nM. This compound is orally bioavailable and has a half-life of 3.6 hours in mouse models. TEAD-IN-12 is primarily utilized in research applications aimed at understanding TEAD-mediated transcriptional regulation and its implications in various pathologies, including cancer and developmental disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3034813-66-3 |
| Applications | TEAD Inhibitor |
| Formula | C22H20F3N3O3 |
| Molecular Weight | 431.41 |
| SMILES | CN1C=C2C=C(C=C(C2=N1)[C@H]3C[C@@H]3C(N4CC(C4)O)=O)OC5=CC=C(C=C5)C(F)(F)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.