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TEAD-IN-20

TEAD Inhibitor

TEAD-IN-20 is a selective TEAD inhibitor that demonstrates potent activity with IC50 values of 0.021 μM and 0.044 μM in TEAD4 FRET and TEAD4 MCF7-Tead cell lines, respectively. This compound effectively disrupts the TEAD signaling pathway, making it a valuable tool for cancer research, particularly in studies related to cellular proliferation and tumorigenesis. Researchers may utilize TEAD-IN-20 to explore the role of TEAD transcription factors in various malignancies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3007592-85-7
Applications	TEAD Inhibitor
Formula	C₂₀H₁₉F₃N₄O₃
Molecular Weight	420.39
SMILES	CN1C=NC2=C(C(N[C@@H]3COC[C@@H](C3)O)=NC=C2C4=CC=C(C=C4)C(F)(F)F)C1=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.