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TEAD-IN-23

TEAD Inhibitor

TEAD-IN-23 is a potent pan-TEAD inhibitor, demonstrating an IC50 of 10 nM. This compound exhibits strong anti-proliferative activity in cancer cell lines such as NCI-H226 and MSTO-211H, leading to complete tumor regression in MSTO-211H xenograft models. TEAD-IN-23 is an essential tool for research in mesothelioma and hepatocellular carcinoma, facilitating insights into TEAD-mediated signaling pathways and potential therapeutic interventions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3074990-47-6
Applications	TEAD Inhibitor
Formula	C₂₃H₁₈ClF₃N₂O₂
Molecular Weight	446.85
SMILES	CC1=CC(C2=CN(C3=C2C(Cl)=NC=C3)CCO)=CC(OC4=CC=C(C=C4)C(F)(F)F)=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.