Fig. 1 · Structure
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TEAD1/3/4-IN-1
TEAD1/3/4 Inhibitor
TEAD1/3/4-IN-1 is an orally active inhibitor targeting the TEAD1, TEAD3, and TEAD4 proteins. It effectively disrupts the YAP/TAZ-TEAD interaction, exhibiting an EC50 of 2 nM. This compound demonstrates anti-proliferative activity in NCI-H226 lung squamous cell carcinoma cells, making it a valuable tool for investigating TEAD-related signaling pathways in cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2762619-63-4 |
| Applications | TEAD1/3/4 Inhibitor |
| Formula | C18H13F4N5O2 |
| Molecular Weight | 407.32 |
| SMILES | O=C(N1CC(C1)N2C(N(C3=NC=CN=C32)C4=CC=C(C(F)(F)F)C=C4)=O)C(F)=C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.