Fig. 1 · Structure
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Tebuquine
Antimalarial Agent
Tebuquine (WR228258) is a 4-aminoquinoline compound that functions as a potent antimalarial agent targeting Plasmodium falciparum. It exhibits strong inhibitory activity against both chloroquine-sensitive (HB3 strain) and chloroquine-resistant (K1 strain) strains, with IC50 values of 0.9 nM and 20.8 nM, respectively. Tebuquine is valuable for research into malaria treatment and the mechanisms of resistance in Plasmodium species.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 74129-03-6 |
| Applications | Antimalarial Agent |
| Formula | C26H25Cl2N3O |
| Molecular Weight | 466.40 |
| Synonyms | WR228258 |
| SMILES | ClC1=CC=C(C2=CC(NC3=C4C=CC(Cl)=CC4=NC=C3)=CC(CNC(C)(C)C)=C2O)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
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| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.