Fig. 1 · Structure
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Tedisamil
Antiarrhythmic Agent
Tedisamil is an antiarrhythmic agent primarily targeting the transient outward potassium current (I(to)) in the atrium, leading to a significant reduction in heart rate. This compound also inhibits various potassium currents, including IK and K(ATP), as well as PKA-activated chloride channels, ultimately prolonging the cardiac action potential and QT interval. Tedisamil demonstrates effective antiarrhythmic properties against ventricular arrhythmias and atrial flutter in preclinical animal models, making it a valuable tool for cardiovascular research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 90961-53-8 |
| Applications | Antiarrhythmic Agent |
| Formula | C19H32N2 |
| Molecular Weight | 288.47 |
| Synonyms | KC-8857 |
| SMILES | [C@@H](CN1CC2CC2)(C3)C4(CCCC4)[C@@H](C1)CN3CC5CC5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.