Telomeric G4s Ligand 2 is a selective ligand that targets telomeric G-quadruplex (G4) structures, exhibiting an IC50 value of 0.4 μM. This compound binds to dimeric telomeric G4 and inhibits the functions of DHX36 and BLM helicases. It activates both cGAS-STING and TERRA-ZBP1 pathways, leading to induction of autophagy and G2/M cell cycle arrest, demonstrating significant antiproliferative effects across various cancer cell lines. This reagent is useful for investigating mechanisms underlying colorectal cancer.
Telomeric G4s Ligand 2 is a selective ligand that targets telomeric G-quadruplex (G4) structures, exhibiting an IC50 value of 0.4 μM. This compound binds to dimeric telomeric G4 and inhibits the functions of DHX36 and BLM helicases. It activates both cGAS-STING and TERRA-ZBP1 pathways, leading to induction of autophagy and G2/M cell cycle arrest, demonstrating significant antiproliferative effects across various cancer cell lines. This reagent is useful for investigating mechanisms underlying colorectal cancer.
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