Fig. 1 · Structure
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tert-Butyl (8-aminooctyl)carbamate
PROTAC Linker
tert-Butyl (8-aminooctyl)carbamate is a versatile PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). It features an alkane chain with both terminal amine and Boc-protected amino groups, providing reactive sites for coupling with carboxylic acids, activated NHS esters, and carbonyls. The Boc group can be readily deprotected under mild acidic conditions, yielding a free amine for further functionalization and applications in targeted protein degradation research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 88829-82-7 |
| Applications | PROTAC Linker |
| Formula | C13H28N2O2 |
| Molecular Weight | 244.37 |
| Synonyms | 1-Boc-1,8-diaminooctane |
| SMILES | NCCCCCCCCNC(OC(C)(C)C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.