Fig. 1 · Structure
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Tesirine intermediate-2
Tesirine Intermediate
Tesirine intermediate-2 is a key intermediate in the synthesis of Tesirine, a DNA small channel crosslinker derived from pyrrole benzodiazepine (PBD) dimers. This compound exhibits potent cytotoxic effects and is crucial for the development of Antibody-Drug Conjugates (ADCs). The resulting ADCs incorporate SG3199 as their warhead component, demonstrating significant anticancer cell activity, making Tesirine intermediate-2 valuable in cancer research and therapeutic applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1430738-34-3 |
| Applications | Tesirine Intermediate |
| Formula | C40H55N5O10Si |
| Molecular Weight | 793.98 |
| SMILES | CC(C)(C)[Si](C)(C)O[C@@H]1N(C2=CC(O)=C(OC)C=C2C(N3[C@@]1([H])CC(C)=C3)=O)C(OCC4=CC=C(C=C4)NC([C@H](C)NC([C@H](C(C)C)NC(OCC=C)=O)=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.