Fig. 1 · Structure
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Tetraethyl butane-1,4-diylbis(phosphoramidate)
PROTAC Linkers
Tetraethyl butane-1,4-diylbis(phosphoramidate) serves as an alkyl chain-based linker for PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the construction of bifunctional molecules that can target and degrade specific proteins through the ubiquitin-proteasome system. It is essential for researchers developing PROTACs aimed at therapeutic interventions in various diseases, including cancer and neurodegenerative disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 720707-93-7 |
| Applications | PROTAC Linkers |
| Formula | C12H30N2O6P2 |
| Molecular Weight | 360.32 |
| SMILES | O=P(OCC)(OCC)NCCCCNP(OCC)(OCC)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.