Fig. 1 · Structure
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Tetraxetan
Chelating Agent
Tetraxetan (DOTA) is a macrocyclic chelating agent that effectively forms stable coordination complexes with various metal ions, including 68Ga, 111In, and 177Lu. Its ability to conjugate with targeting molecules, such as RGD peptides and folic acid, allows for directed targeting of specific biomolecules or cells. Tetraxetan is particularly useful in imaging studies of tumors, including melanoma and cancers that express folate receptors, such as cervical cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 60239-18-1 |
| Applications | Chelating Agent |
| Formula | C16H28N4O8 |
| Molecular Weight | 404.42 |
| Synonyms | DOTA |
| SMILES | O=C(O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.