Fig. 1 · Structure
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TG2-179-1
BAP1 Inhibitor
TG2-179-1 is a potent inhibitor of BAP1, targeting the deubiquitinase (DUB) activity by covalently binding to its active site. This compound demonstrates significant cytotoxic effects, resulting in impaired cellular replication and enhanced apoptosis. TG2-179-1 is particularly relevant for research into colon cancer, providing valuable insights into DUB-associated pathways and their role in tumorigenesis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1135023-19-6 |
| Applications | BAP1 Inhibitor |
| Formula | C22H14ClFN4O2S2 |
| Molecular Weight | 484.95 |
| SMILES | N#CC1=C(NC(CSC2=NN=C(C3=CC=C(Cl)C=C3)O2)=O)SC(C)=C1C4=CC=C(C=C4)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.