TGF-β1/Smad-IN-1

Catalog No.: A37029
TGF-β1/Smad Inhbitor
TGF-β1/Smad-IN-1 is a potent inhibitor of the TGF-β1/Smad signaling pathway, which plays a crucial role in the regulation of fibrotic processes. This compound effectively reduces the expression of fibrosis markers, such as α-SMA and COL1A1, induced by TGF-β1, demonstrating significant antifibrotic activity. TGF-β1/Smad-IN-1 is valuable for research applications focused on hepatic fibrosis and related fibrotic disorders.
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5mg
10mg
50mg
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Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTGF-β1/Smad-IN-1 is a potent inhibitor of the TGF-β1/Smad signaling pathway, which plays a crucial role in the regulation of fibrotic processes. This compound effectively reduces the expression of fibrosis markers, such as α-SMA and COL1A1, induced by TGF-β1, demonstrating significant antifibrotic activity. TGF-β1/Smad-IN-1 is valuable for research applications focused on hepatic fibrosis and related fibrotic disorders.
Product Information
Catalog NumA37029
FormulaC18H19ClN2O6
Molecular Weight394.81
CAS Number3097194-50-5
SMILESClC(C=C1NCC2=CC[C@@]3([H])[C@]2([H])[C@H](OC)OC=C3C(OC)=O)=C(C=C1)[N+]([O-])=O
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