Fig. 1 · Structure
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TGFBR1-IN-2
TGFBR1 Inhibitor
TGFBR1-IN-2 is a potent TGFBR1 inhibitor that targets the transforming growth factor-beta signaling pathway. This compound exhibits significant antibacterial activity, particularly against Mycobacterium tuberculosis. TGFBR1-IN-2 demonstrates effective inhibition of both non-replicating and persistent forms of the bacteria, making it a valuable tool for research on tuberculosis treatment and the modulation of immune responses. Additionally, it serves as a substrate for cytochrome P450 enzymes, which may influence its metabolic profile in biological systems.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 733806-89-8 |
| Applications | TGFBR1 Inhibitor |
| Formula | C19H15N5 |
| Molecular Weight | 313.36 |
| SMILES | CC1=NC(C2=NC(NC3=CC=NC=C3)=C4C=CC=CC4=N2)=CC=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.