Fig. 1 · Structure
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TGFβRI-IN-4
Cat. No.
A84913
CAS
2421135-03-5
TGF-βR1 Inhibitor
TGFβRI-IN-4 is a potent and orally bioavailable inhibitor of the TGF-β receptor type I (TGFβRI), demonstrating IC50 values of 44 nM and 42.5 nM against ALK5 and NIH3T3 cell lines, respectively. This compound effectively inhibits TGF-β signaling, leading to suppression of tumor growth and reduction in tumor weight in xenograft models. TGFβRI-IN-4 is particularly valuable for research into cancer biology and therapeutic interventions targeting the TGF-β pathway.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2421135-03-5 |
| Applications | TGF-βR1 Inhibitor |
| Formula | C23H25F2N5O2 |
| Molecular Weight | 441.47 |
| SMILES | CC(O)(C1=CC(NC2=CC(OC3=CN(N=C3C4CC(F)(C4)F)C5CC5)=CC=N2)=CC=N1)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.