TGR-1202 (Umbralisib)

Catalog No.: A16277

PI3Kδ inhibitor

TGR-1202 (Umbralisib)

TGR-1202 (Umbralisib) Chemical Structure

CAS NO. 1532533-67-7

TGR-1202 is an orally available, next generation PI3Kδ inhibitor, inhibits PI3Kδ activity in enzyme and cell based assays with IC50 and EC50 values of 22.2 and 24.3 nM respectively.

Availability: In stock

Package Price Qty
5 mg
$120.00
10 mg
$220.00
50 mg
$580.00
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Biological Activity

TGR-1202 is an orally available, next generation PI3Kδ inhibitor, inhibits PI3Kδ activity in enzyme and cell based assays with IC50 and EC50 values of 22.2 and 24.3 nM respectively.
In vitro (25°C) DMSO Warmed: 92 mg/mL (160.96 mM)
Water Insoluble
Ethanol Warmed: 6 mg/mL
In vivo 2% DMSO+30% PEG 300+2% Tween 80+H2O 2 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.5 mL 87.48 mL 174.96 mL
0.5 mM 3.5 mL 17.5 mL 34.99 mL
1 mM 1.75 mL 8.75 mL 17.5 mL
5 mM 0.35 mL 1.75 mL 3.5 mL

*The above data is based on the productmolecular weight 571.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16277
Actions Inhibitor
CAS No. 1532533-67-7
Formula C31H24F3N5O3
M. Wt 571.55
Purity >98%
Synonyms RP5264, TGR1202, TGR 1202, RP-5264, RP 5264
SMILES CC(C)OC1=C(C=C(C=C1)C2=NN(C3=C2C(=NC=N3)N)C(C)C4=C(C(=O)C5=C(O4)C=CC(=C5)F)C6=CC(=CC=C6)F)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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