TGR5 agonist 6

Catalog No.: A60420
G protein-coupled Bile Acid Receptor 1 Agonist
TGR5 agonist 6 is a selective G protein-coupled bile acid receptor 1 agonist. This compound demonstrates notable and prolonged blood glucose-lowering effects, while maintaining an acceptable safety profile. Its design as a non-systemic, gut-targeted agent makes it valuable for research applications focused on metabolic disorders and glucose homeostasis.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTGR5 agonist 6 is a selective G protein-coupled bile acid receptor 1 agonist. This compound demonstrates notable and prolonged blood glucose-lowering effects, while maintaining an acceptable safety profile. Its design as a non-systemic, gut-targeted agent makes it valuable for research applications focused on metabolic disorders and glucose homeostasis.
Product Information
Catalog NumA60420
FormulaC42H48Cl2N6O6
Molecular Weight803.77
CAS Number2925211-47-6
SMILESO=C(N1CCCCCC(NCCCCCCNC(CCC(C=C2Cl)=C(C=C2OC3=C(C=NC=C3)C(N4CCN(C5=C4C=CC=C5)C6CC6)=O)Cl)=O)=O)C=CC1=O
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