Fig. 1 · Structure
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TH-Z145
FPPS Inhibitor
TH-Z145 is a lipophilic bisphosphonate that acts as a farnesyl pyrophosphate synthase (FPPS) inhibitor, with an IC50 of 210 nM. This compound demonstrates significant inhibition of the mevalonate pathway, impacting isoprenoid biosynthesis. TH-Z145 is valuable for research applications exploring its effects on bone metabolism, cancer progression, and various diseases linked to dysregulated cholesterol synthesis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2260887-57-6 |
| Applications | FPPS Inhibitor |
| Formula | C16H28O7P2 |
| Molecular Weight | 394.34 |
| SMILES | O=P(O)(C(P(O)(O)=O)CC1=CC(OCCCCCCCC)=CC=C1)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.