Fig. 1 · Structure
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TH5427
Anti-cancer Agent
TH5427 is a targeted inhibitor of NUDT5, crucial for studying ADP-ribose metabolism. This compound effectively blocks progestin-dependent, PAR-derived nuclear ATP synthesis, disrupting chromatin remodeling, gene regulation, and proliferation in breast cancer cells. As NUDT5 has been identified as a regulator of hormone-dependent gene expression, TH5427 serves as a valuable tool for investigating its role in breast cancer biology and therapeutic potential.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2253744-56-6 |
| Applications | Anti-cancer Agent |
| Formula | C20H20Cl2N8O3 |
| Molecular Weight | 491.33 |
| SMILES | O=C(N1C)N(C)C2=C(N(CC3=NN=C(C4=CC=C(Cl)C(Cl)=C4)O3)C(N5CCNCC5)=N2)C1=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.