Fig. 1 · Structure
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Thailanstatin A
RNA Splicing Inhibitor
Thailanstatin A is a potent inhibitor of eukaryotic RNA splicing, with an IC50 of 650 nM. It functions by non-covalently binding to the SF3b subunit of the U2 snRNA subcomplex within the spliceosome, displaying low-nM to sub-nM IC50 values across various cancer cell lines. Additionally, Thailanstatin A serves as an effective payload for antibody-drug conjugates (ADCs), including its conjugation to lysines on trastuzumab for the development of "linker-less" ADCs.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1426953-21-0 |
| Applications | RNA Splicing Inhibitor |
| Formula | C28H41NO9 |
| Molecular Weight | 535.63 |
| SMILES | O=C(O)C[C@@H](O[C@H](/C=C/C(C)=C/C[C@H]1[C@@H](C)C[C@@H](NC(/C=C\[C@@H](OC(C)=O)C)=O)[C@@H](C)O1)[C@H]2O)C[C@]32CO3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.