Fig. 1 · Structure
Documents & Downloads
tHGA
Cat. No.
A76477
CAS
43230-43-9
Lipoxygenase Inhibitor
tHGA is a potent lipoxygenase inhibitor with demonstrated anti-inflammatory properties. It effectively inhibits soybean 15-lipoxygenase (15-LOX) with an IC50 of 0.42 μM and exhibits concentration-dependent inhibition of 5-lipoxygenase (5-LOX) product synthesis, particularly cysteine leukotriene LTC(4), with an IC50 of 1.80 μM. Notably, tHGA shows no cytotoxicity and operates through a dual inhibition mechanism targeting both LOX and COX-2, with enhanced selectivity for 5-LOX and COX-2 (IC50 of 0.40 μM). This compound is valuable for research applications focused on inflammatory processes and lipoxygenase-related signaling pathways.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 43230-43-9 |
| Applications | Lipoxygenase Inhibitor |
| Formula | C18H24O4 |
| Molecular Weight | 304.38 |
| SMILES | OC1=CC(O)=C(C(O)=C1C(C)=O)C/C=C(CC/C=C(C)\C)\C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.