tHGA is a potent lipoxygenase inhibitor with demonstrated anti-inflammatory properties. It effectively inhibits soybean 15-lipoxygenase (15-LOX) with an IC50 of 0.42 μM and exhibits concentration-dependent inhibition of 5-lipoxygenase (5-LOX) product synthesis, particularly cysteine leukotriene LTC(4), with an IC50 of 1.80 μM. Notably, tHGA shows no cytotoxicity and operates through a dual inhibition mechanism targeting both LOX and COX-2, with enhanced selectivity for 5-LOX and COX-2 (IC50 of 0.40 μM). This compound is valuable for research applications focused on inflammatory processes and lipoxygenase-related signaling pathways.
tHGA is a potent lipoxygenase inhibitor with demonstrated anti-inflammatory properties. It effectively inhibits soybean 15-lipoxygenase (15-LOX) with an IC50 of 0.42 μM and exhibits concentration-dependent inhibition of 5-lipoxygenase (5-LOX) product synthesis, particularly cysteine leukotriene LTC(4), with an IC50 of 1.80 μM. Notably, tHGA shows no cytotoxicity and operates through a dual inhibition mechanism targeting both LOX and COX-2, with enhanced selectivity for 5-LOX and COX-2 (IC50 of 0.40 μM). This compound is valuable for research applications focused on inflammatory processes and lipoxygenase-related signaling pathways.
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