THIP-d4, a deuterium-labeled derivative of THIP (Gaboxadol), selectively targets extrasynaptic GABAA receptors (eGABARs) with a reported EC50 of 13 μM for δ-GABAAR. This compound demonstrates strong potentiation of GABAA-mediated currents in layer 2/3 neurons while having no effect on miniature inhibitory postsynaptic currents (IPSCs). THIP-d4 is valuable for research into sleep disorders and other neurological conditions related to GABAergic signaling.
THIP-d4, a deuterium-labeled derivative of THIP (Gaboxadol), selectively targets extrasynaptic GABAA receptors (eGABARs) with a reported EC50 of 13 μM for δ-GABAAR. This compound demonstrates strong potentiation of GABAA-mediated currents in layer 2/3 neurons while having no effect on miniature inhibitory postsynaptic currents (IPSCs). THIP-d4 is valuable for research into sleep disorders and other neurological conditions related to GABAergic signaling.
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